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Lipitor at raising good cholesterol levels and has fewer side effects. This may not be a complete list of all interactions that may occur. Ask your health care provider if simvastatin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Maintain a desirable weight. Keep container tightly closed. Caduet is a combination of a statin Lipitor and a blood pressure-lowering drug called Norvasc. Vytorin is a combination of a statin and a cholesterol absorption inhibitor simvastatin and ezetimibe. acarbose

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Pan, T. M. Effect of red mold rice on antifatigue and exercise-related changes in lipid peroxidation in endurance exercise. Appl. Nakanishi, T. Isolation and identification of hypotensive principles in red-mold rice. Chem Pharm Bull. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study.

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Overall, the risks of taking statins are very low -- lower than the risks from taking two a day, McBride says. Fluconazole: May increase the serum concentration of Simvastatin. Feng XY, Wang XF Li X. Analysis of 116 cases of hyperlipemia in treatment with Xuezhikang. Statins boost HDL, the "good" cholesterol, by up to 15%. Hua D. Comparative Observation of simvastatin and Xuezhikang for patients with hyperlipidemia.

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Yamaguchi, A. Evaluation of photo-mutagenicity and photo-cytotoxicity of food coloring agents. Protease Inhibitors: May increase the serum concentration of Simvastatin. With this condition, muscles all over the body become painful and weak. The severely damaged muscles release proteins into the blood that collect in the kidneys. The kidneys can become damaged trying to eliminate a large amount of muscle breakdown caused by statin use. This can ultimately lead to or even death. Fortunately, rhabdomyolysis is extremely rare. Fisher Center for Alzheimer's Research Foundation: “Cholesterol-Lowering Statins May Ward off Dementia.

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Store colchicine at room temperature, between 68 and 77 degrees F 20 and 25 degrees C in a tightly closed container. Store away from heat, light, and moisture. Do not store in the bathroom. Keep colchicine out of the reach of children and away from pets. If you experience any unexplained joint or muscle pain, tenderness, or weakness while taking statins, you should call your doctor immediately. Pregnant women or those with active or chronic liver disease should not use statins. Ma YL. Observation of 30 cases of hypercholesterolemia in treatment with Xuezhikang. Store simvastatin at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep simvastatin out of the reach of children and away from pets. Researchers found that statins were associated with an almost 50 percent higher risk of developing type 2 diabetes, even after adjusting for other factors. Lansheng, G. Comparison of the effects of Xuezhikang and Simvastatin on lipid profile modification in patients with hypercholesterolemia. Do not take any red yeast rice products while you are taking simvastatin because some red yeast rice products may also contain a statin called lovastatin. Taking simvastatin and red yeast rice products together can increase your risk of serious muscle and liver problems. Palmucci, L. Chinese red rice depletes muscle coenzyme Q10 and maintains muscle damage after discontinuation of statin treatment. Olivia Williams; Anne-Marie Jacks; Jim Davis; Sabrina Martinez 1998.

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Kong YM, Gao H Liu XL. Clinical observations of the lipid-lowering effects of Xuezhikang and elastase. Email-Lab work is ordered for me-I'll have that done Monday. The most common type of massage is Swedish massage therapy. It involves soft, long, kneading strokes, as well as light, rhythmic, tapping strokes, on topmost layers of muscles. This is also combined with movement of the joints. By relieving muscle tension, Swedish therapy can be both relaxing and energizing. And it may even help after an injury. Annu. Rev. Pharmacol. Toxicol. In those cases, he believes that the benefits of the drug usually outweigh their risks. Based on 10 mg-dose of ezetimibe. But studies of the drugs paint a starkly different picture. In studies where patients are randomly assigned to take a statin or a placebo pill, the rates of side effects reported by each group are nearly identical, leading many doctors to wonder if the side effects are really due to the medications or if something else, like the nocebo effect, might be at work. In the nocebo effect -- the opposite of the -- a person suffers side effects from a fake medicine. Zeng TK. Observation of the therapeutic effects of Xuezhikang for treatment of 77 elderly with hyperlipidemia. Consider use of pravastatin, rosuvastatin, or pitavastatin if statin therapy is needed. AUC0-24h for total ezetimibe. Comparison of Zhibituo and simvastatin for their effects on hyperlipidemia. It may take up to 4 weeks before you get the full benefit of this drug. Shake bottle well for at least 20 seconds before using. Fink-Gremmels, J. Mutagenicity of commercial Monascus fermentation products and the role of citrinin contamination. Mutat. Rogers JD, Zhao J, Liu L, et al. Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. topiramate

Important information

Some people who take statins have reported memory loss and confusion. Simvastatin has important interactions with juice and other drugs, including some that are commonly used for the treatment of cardiovascular disease. Using simvastatin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. If these rare effects occur, talk to your doctor. Hsieh, P. S. and Tai, Y. H. Aqueous extract of Monascus purpureus M9011 prevents and reverses fructose-induced hypertension in rats. J Agric. Xu JM, Chen SX Hu WY Cai NS Xu Q Wu ZG Sun KX. Zhibituo vs. placebo treatment of hyperlipidemia a double blind randomized and multicenter study.

AUC of total ezetimibe approximately 55%

Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats such as LDL, triglycerides and raise "good" cholesterol HDL in the blood. It belongs to a group of drugs known as "statins. Do not eat grapefruit or drink grapefruit juice while you are using colchicine. Lai, M. M. Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Your is supposed to carry oxygen to all parts of your body, including your muscle. Endo, A. Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiot. Gordon RY, Cooperman T, Obermeyer W, Becker DJ. Marked variability of monacolin levels in commercial red yeast rice products: buyer beware! Yang, C. S. Inhibitory effect of red koji extracts on mushroom tyrosinase. J Agric. doxycycline generic medication

Sept 10, 2002; vol 106: pp 1327-1332

Suspension can be started simultaneously with diet. Manufacturer's labeling: Liver enzyme tests at baseline and repeated when clinically indicated. Measure CPK when myopathy is being considered or may measure CPK periodically in high risk patients eg, drug-drug interaction. Lipid panel should be analyzed after 4 weeks of therapy and periodically thereafter. Grapefruit Juice: May increase the serum concentration of Simvastatin. Zhao, Y. C. Effect of xuezhikang on cardiovascular events and mortality in elderly patients with a history of myocardial infarction: a subgroup analysis of elderly subjects from the China Coronary Secondary Prevention Study. Call your doctor right away if you have dark-colored urine, diarrhea, a fever, muscle cramps or spasms, muscle pain or stiffness, or feel very tired or weak. These could be symptoms of a serious muscle problem called rhabdomyolysis, which can cause kidney problems. These drugs work inside the intestine, where they bind to bile and prevent it from being reabsorbed into the circulatory system. Bile is made largely from cholesterol, so these drugs work by reducing the body's supply of cholesterol, thus lowering total and LDL cholesterol. The most common side effects are constipation, gas, and upset stomach. Guo XL, Li Y Yin GN. Xuezhikang for treatment of 30 cases of hyperlipidemia.

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CoQ10 supplements on your own, however. Work with your doctor when you take any supplement. Wong, H. C. and Bau, Y. S. Pigmentation and Antibacterial Activity of Fast Neutron- and X-Ray-induced Strains of Monascus purpureus Went. Quan SL, Wang W Qu XW. The effect of Xuezhikang and simvastatin on lipid of hypercholesterolemia. Brown, D. Lipid-lowering effects of monascus purpureus red yeast rice. Group; Link E; Parish S; Armitage J; Bowman L; Heath S; Matsuda F; Gut I; Lathrop M; Collins R 2008. pdf. N Engl J Med. How Much Do You Need? If pregnancy occurs, VYTORIN should be immediately discontinued. See USP Controlled Room Temperature. LDL-C reduction of 41% with the 80-mg dose. Keithley JK, Swanson B, Sha BE, et al. A pilot study of the safety and efficacy of cholestin in treating HIV-related dyslipidemia. price altace rezeptfrei

Common side effects of simvastatin

Simvastatin should be used with extreme caution in CHILDREN younger than 10 years old and in those who have not reached puberty; safety and effectiveness in these children have not been confirmed. Clarithromycin: May increase the serum concentration of Simvastatin. The mean Cmax and AUC of niacin increased 9% and 22%, respectively. The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Bargossi AM, Battino M, Gaddi A, et al. Exogenous CoQ10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Primary or secondary prevention: Note: Treatment initiation using either moderate- or high-intensity statin therapy is recommended in qualifying patients based on ASCVD risk assessment criteria and baseline non-HDL-C and LDL-C values. Dosage should be individualized based on patient characteristics, tolerance to therapy, and with consideration for non-HDL-C and LDL-C treatment goals. CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed. Experts say another problem is that people may suspect statins when other conditions are really causing their symptoms. Li, S. Effect of Xuezhikang, an extract from red yeast Chinese rice, on coronary events in a Chinese population with previous myocardial infarction.

Simvastatin brand names

Retrieved 12 July 2012. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using colchicine while you are pregnant. Colchicine is found in breast milk. If you are or will be breast-feeding while you use colchicine, check with your doctor. Discuss any possible risks to your baby. Tell your doctor if you regularly drink grapefruit juice. Drinking large amounts of grapefruit juice more than 1 quart each day while taking simvastatin may increase your risk of muscle injury and could result in kidney problems. Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates. Evaluate for new-onset diabetes mellitus during therapy; if diabetes develops, continue statin therapy and encourage adherence to a heart-healthy diet, physical activity, a healthy body weight, and tobacco cessation. altace

Use of simvastatin

AUC for total ezetimibe. Gemfibrozil Lopid can affect the muscles. Red yeast can also affect the muscles. Taking gemfibrozil along with red yeast might increase the risk of muscle problems. TriCor may be taken with or without food. Follow the directions on your medicine label. Take TriCor exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Research has not shown that adding niacin, when you already take a statin, further lowers your risk of heart disease. Lilja JJ, Neuvonen M, Neuvonen PJ July 2004. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. This medication may rarely cause problems. VYTORIN and placebo groups, respectively. Diabetes patients - Simvastatin may increase your blood sugar levels. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

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General information about simvastatin

Simvastatin forms and strengths

Xuezhikang capusule in the treatment of hyperlipidemia. The study authors noted, however, that their research only found an association between statin use and diabetes risk. And since the study was limited to white men, it's not clear if the findings would apply to women or other racial groups. AUC after an 80-mg oral dose. Vitamin K Antagonists eg, warfarin: HMG-CoA Reductase Inhibitors may enhance the anticoagulant effect of Vitamin K Antagonists. purchase alesse interaction

How to use simvastatin

Wang SX. Comparison of the therapeutic effects of Xuezhikang and lovastatin. Muscle problems myopathy may occur with simvastatin. The risk of muscle problems may be greater in people who take higher doses of simvastatin, in people older than 64 years old, in females, or in people who have kidney problems or low thyroid function. It may also be greater in those who take it with certain other medicines eg, niacin especially in Chinese patients. Tell your doctor right away if you notice any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or general body discomfort. Tell your doctor if you have muscle problems that persist even after your doctor has told you to stop taking simvastatin.

Consult your doctor before breast-feeding

Food and Drug Administration. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Goldberg expects that most heart patients who need statins will continue to receive them, but with close monitoring of their blood sugar levels. How should I store VYTORIN? There are several different types of prescription drugs that lower LDL. Get to know what each of them does.

How to take simvastatin

Want to know something funny? Begin medication therapy as directed by your doctor. Store at room temperature between 68-77 degrees F 20-25 degrees C away from light and moisture. not store in the bathroom. Keep all medicines away from children and pets.

CycloSPORINE Systemic: May increase the serum concentration of Simvastatin. All statins act by inhibiting 3-hydroxy-3-methylglutaryl HMG coenzyme A reductase. Advicor and Simcor are both combinations of a statin and niacin see below. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Wang AH, Zhang GD. Comparison of the therapeutic effects of Xuezhikang and Lescol for treatment of hyperlipidemia.

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